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Ronnie Coleman HMB XS or Beta-hydroxy beta-methylbutyrate (HMB) is an important metabolite of the essential branched-chain amino acid (BCAA) L-Leucine. Human and animal studies suggest protein breakdown and support significant increases in muscle strength and size when combined with intense resistance training. HMB has also been shown to speed strength and muscle mass gains in strength athletes, and improve endurance performance in cyclists and runners.